M1i-124

Chemical Structure : M1i-124

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货号: PC-24363Not For Human Use, Lab Use Only.

M1i-124 is a first-in-class, small-molecule inhibitor of BCL10-MALT1 interaction with IC50 of 16 uM, abrogates MALT1 scaffolding and protease activities, promotes degradation of BCL10 and MALT1 proteins.

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生物&药学活性

M1i-124 is a first-in-class, small-molecule inhibitor of BCL10-MALT1 interaction with IC50 of 16 uM, abrogates MALT1 scaffolding and protease activities, promotes degradation of BCL10 and MALT1 proteins.
M1i-124 shows binding affinity of M1i-124 to immobilized full-length MALT1 with SPR KD of 296 uM.
M1i-124 (1 uM) inhibits MALT1-dependent cytokine expression and secretion in stimulated Jurkat T cells and primary splenocytes.
M1i-124 (1 uM) inhibits MALT1 protease and scaffolding functions, and MALT1-dependent cytokine secretion, in ABC-DLBCL cells, induces specific protein loss for BCL10 and MALT1.
M1i-124 selectively inhibits ABC-DLBCL cell proliferation and survival of MALT1-dependent ABC-DLBCL cells, but not MALT1-independent GCB-DLBCL cells.
M1i-124 (50 mg/kg i.p. per day) inhibits ABC-DLBCL lymphoma tumor growth in a xenograft mouse model.

物理化学性质&存储条件

分子量	594.65
分子式	C29H26N2O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-methylenebis(N-(benzo[d][1,3]dioxol-5-ylmethyl)benzenesulfonamide)

参考文献

1. Kang H, et al. J Clin Invest. 2025 Apr 15;135(8):e164573.

M1i-124

生物&药学活性

物理化学性质&存储条件

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M1i-124

生物&药学活性

物理化学性质&存储条件

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