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首页-小分子抑制剂&激动剂-Others-GRK (GPCRK)-M119
M119

Chemical Structure : M119

CAS No.: 500533-94-8

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M119

货号: PC-27336Not For Human Use, Lab Use Only.

M119 is a specific inhibitor of G protein beta gamma subunit Gβγ, inhibits Gβγ-mediated signalling, interferes with Gβγ binding to GRK2, thereby inhibiting GRK2 membrane localization and Gβγ-mediated GPCR phosphorylation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

M119 is a specific inhibitor of G protein beta gamma subunit Gβγ, inhibits Gβγ-mediated signalling, interferes with Gβγ binding to GRK2, thereby inhibiting GRK2 membrane localization and Gβγ-mediated GPCR phosphorylation.

物理化学性质&存储条件

分子量 370.36
分子式 C20H18O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4,5,6-Trihydroxy-3-oxo-3H-xanthen-9-yl)cyclohexane-1-carboxylic acid

参考文献

1. Tabetha M Bonacci, et al. Science. 2006 Apr 21;312(5772):443-6.

2. Mathews JL, et al. J Neurosci. 2008 Nov 19;28(47):12183-9.

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