LumiPK

Chemical Structure : LumiPK

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货号: PC-25624Not For Human Use, Lab Use Only.

LumiPK is an environment-sensitive fluorescent tracer designed to monitor allosteric binding to the liver isoform of pyruvate kinase (PKL) (λ ex=450 nm, λ em=550 nm), displays strong PKL binding with SPR KD of 37 nM.

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生物&药学活性

LumiPK is an environment-sensitive fluorescent tracer designed to monitor allosteric binding to the liver isoform of pyruvate kinase (PKL) (λ ex=450 nm, λ em=550 nm), displays strong PKL binding with SPR KD of 37 nM.
LumiPK dispplays PKL selectivity (37-fold) over PKM2
LumiPK integrates an environment-sensitive 4-sulfamonyl-7-aminobenzoxadiazole fluorophore into a potent allosteric modulator scaffold.
LumiPK high potency (EC50=18.4 nM) in cellular experiments.
LumiPK is a useful tool for tracking allosteric PKL ligand engagement in living cells.

物理化学性质&存储条件

分子量	451.46
分子式	C20H17N7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1H-pyrazol-3-yl)methyl)-6-((7-(dimethylamino)benzo[c][1,2,5]oxadiazol-4-yl)sulfonyl)phthalazin-1(2H)-one

参考文献

1. Nilsson O, et al. Angew Chem Int Ed Engl. 2025 Oct 13;64(42):e202513969.

LumiPK

生物&药学活性

物理化学性质&存储条件

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LumiPK

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