LpxH inhibitor AZ1

Chemical Structure : LpxH inhibitor AZ1

CAS No.: 901260-40-0

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货号: PC-25649Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LpxH inhibitor AZ1 is the first reported inhibitor of LpxH with Ki of 53.4 nM for E. coli LpxH, shows MIC of 0.25 ug/mL against E. coli MG1655 ΔtolC, AZ1 inhibits 75% of the activity of K. pneumoniae LpxH at 1 uM.
LpxH catalyzes the fourth step in the synthesis of lipid A, the outer membrane anchor of lipopolysaccharide (LPS).

物理化学性质&存储条件

分子量	453.48
分子式	C21H22F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-((4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)indolin-1-yl)ethan-1-one

参考文献

1. Dome PA, et al. ACS Infect Dis. 2025 Oct 27. doi: 10.1021/acsinfecdis.5c00625.

2. Asha S Nayar, et al. J Bacteriol. 2015 May;197(10):1726-34.