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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-Lorundrostat
Lorundrostat

Chemical Structure : Lorundrostat

CAS No.: 1820940-17-7

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Lorundrostat (MT-4129, MT4129)

货号: PC-24474Not For Human Use, Lab Use Only.

Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase) Ki values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1, reduces systolic blood pressure.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase) Ki values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1, reduces systolic blood pressure.

物理化学性质&存储条件

分子量 451.58
分子式 C24H33N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(trans-4-Acetamidocyclohexyl)-2-(4-(5-(p-tolyl)-1,2,4-triazin-3-yl)piperazin-1-yl)acetamide

参考文献

1. Laffin LJ, et al. JAMA. 2023 Sep 26;330(12):1140-1150.

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