Lomitapide | MTP inhibitor | Probechem Biochemicals

Chemical Structure : Lomitapide

CAS No.: 182431-12-5

加入收藏

Lomitapide (AEGR-733, BMS-201038)

货号: PC-24772Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥580	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Lomitapide (AEGR-733, BMS-201038) is a highly potent inhibitor of microsomal triglyceride-transfer protein (MTP), inhibits triglyceride transfer of human MTP in vitro with IC50 of 0.5 nM, inhibits secretion of apoB from HepG2 cells with IC50 of 0.8 nM.
Lomitapide inhibited the production of lipoprotein particles in rodent models and normalized plasma lipoprotein levels in Watanabe-heritable hyperlipidemic (WHHL) rabbits, which are a model for human homozygous familial hypercholesterolemia.

物理化学性质&存储条件

分子量	693.73
分子式	C39H37F6N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide

参考文献

1. Robl JA, et al. J Med Chem. 2001 Mar 15;44(6):851-6.

2. Cuchel M, et al. N Engl J Med. 2007 Jan 11;356(2):148-56.

3. J R Wetterau, et al. Science. 1998 Oct 23;282(5389):751-4.

Lomitapide (AEGR-733, BMS-201038)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Lomitapide (AEGR-733, BMS-201038)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.