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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-Lometrexol
Lometrexol

Chemical Structure : Lometrexol

CAS No.: 106400-81-1

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Lometrexol (DDATHF)

货号: PC-26409Not For Human Use, Lab Use Only.

Lometrexol (DDATHF) is an antipurine antifolate and inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), also inhibits serine hydroxymethyltransferase (SHMT) with ITC KD of 2 uM.

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10 mg ￥2180 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lometrexol (DDATHF) is an antipurine antifolate and inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), also inhibits serine hydroxymethyltransferase (SHMT) with ITC KD of 2 uM.

物理化学性质&存储条件

分子量 443.46
分子式 C21H25N5O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(2-((R)-2-Amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamic acid

参考文献

1. Taylor EC, et al. J Med Chem. 1985 Jul;28(7):914-21.

2. Paiardini A, et al. ChemMedChem. 2015 Mar;10(3):490-7.

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