Linker-free PROTAC Pro-DA | BCR-ABL degrader | Probechem Biochemicals

Chemical Structure : Linker-free PROTAC Pro-DA

加入收藏

Linker-free PROTAC Pro-DA (Proline-Dasatinib analog)

货号: PC-24675Not For Human Use, Lab Use Only.

Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM.
Pro-DA-mediated decrease of BCR-ABL protein levels was largely blunted in GID4 knockout K562 cells.
ro-DA induces interaction between EML4-ALK and GID4 and subsequently promoted BCR-ABL ubiquitylation.
GID4, serving as the substrate receptor for the CTLH E3 ligase complex, is responsible for recognizing substrates featuring an N-terminal proline.

物理化学性质&存储条件

分子量	541.07
分子式	C25H29ClN8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(4-prolylpiperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide

参考文献

1. Jianchao Zhang, et al. Nature Communications volume 16, Article number: 4794 (2025).

Linker-free PROTAC Pro-DA (Proline-Dasatinib analog)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Linker-free PROTAC Pro-DA (Proline-Dasatinib analog)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.