Lexibulin | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Lexibulin

CAS No.: 917111-44-5

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Lexibulin (CYT-997, CYT997)

货号: PC-42619Not For Human Use, Lab Use Only.

Lexibulin (CYT997) is an orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Lexibulin (CYT997) is an orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
Lexibulin (CYT997) inhibits a broad selection of cancer cell lines with IC50 of <100 nM; blocks the cell cycle at the G2-M boundary and increases phosphorylated Bcl-2, expression of cyclin B1.
Lexibulin (CYT997) is orally bioavailable, and efficacious in a range of in vivo cancer models.

物理化学性质&存储条件

分子量	434.534
分子式	C24H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-ethyl-N'-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]-

参考文献

1. Burns CJ, et al. Mol Cancer Ther. 2009 Nov;8(11):3036-45.

2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4639-42.

3. Burns CJ, et al. J Pharmacol Exp Ther. 2011 Dec;339(3):799-806.

Lexibulin (CYT-997, CYT997)

生物&药学活性

物理化学性质&存储条件

参考文献

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Lexibulin (CYT-997, CYT997)

生物&药学活性

物理化学性质&存储条件

参考文献

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