Lexacalcitol | Vitamin D analog | Probechem Biochemicals

Chemical Structure : Lexacalcitol

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Lexacalcitol (KH-1060, KH1060)

货号: PC-45802Not For Human Use, Lab Use Only.

Lexacalcitol (KH1060) is a potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.

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生物&药学活性

Lexacalcitol (KH1060) is a potent 20-epi analogue of 1,25-dihydroxyvitamin D3 that inhibits glucocorticoid-induced skin atrophy.
Lexacalcitol stimulates the synthesis of sulphated glycosaminoglycans and hydroxyproline in skin treated with betamethasone.
Lexacalcitol strongly stimulated the expression of TGF-beta 1 in betamethasone-impaired granulation tissue; a potent vitamin D receptor agonist.

物理化学性质&存储条件

分子量	460.689
分子式	C29H48O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-

参考文献

1. Gniadecki R, et al. Br J Pharmacol. 1994 Oct;113(2):439-44.

2. Gniadecki R, et al. J Endocrinol. 1994 Jun;141(3):411-5.

3. Sandler S, et al. Immunol Lett. 1994 Jun;41(1):73-7.

Lexacalcitol (KH-1060, KH1060)

生物&药学活性

物理化学性质&存储条件

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Lexacalcitol (KH-1060, KH1060)

生物&药学活性

物理化学性质&存储条件

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