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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-Leucettinib-92
Leucettinib-92

Chemical Structure : Leucettinib-92

CAS No.: 2732859-57-1

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Leucettinib-92 (Leucettinib 92)

货号: PC-20985Not For Human Use, Lab Use Only.

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively.
Leucettinib-92 preferably targets CLK1, CLK2, CLK4, DYRK1A and DYRK1B on the Eurofins DiscovRx KinomeScan selectivity panel (468 kinases) at 1 uM.
Leucettinib-92 can penetrate cells and inhibits DYRK1A at low concentrations (from 0.1–0.3 μM) in cell models.

物理化学性质&存储条件

分子量 378.49
分子式 C21H22N4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-2-(adamantan-1-ylamino)-5-(benzo[d]thiazol-6-ylmethylene)-3,5-dihydro-4H-imidazol-4-one

参考文献

1. Emmanuel Deau, et al. J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00884.

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