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首页-抗体药物偶连体和PROTACs-E3 Ligase Ligand-Lenalidomide
Lenalidomide

Chemical Structure : Lenalidomide

CAS No.: 191732-72-6

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Lenalidomide (CC-5013, CC 5013)

货号: PC-20467Not For Human Use, Lab Use Only.

Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase.

规格 价格 库存 数量
100 mg ￥980 In stock
500 mg ￥1580 In stock
1 g ￥2380 In stock
5 g ￥4880 In stock
10 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase.
Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
Lenalidomide (CC-5013) inhibits production of pro inflammatory cytokines TNF-α, IL-1, IL-6, IL-12 and elevates the production of anti-inflammatory cytokine IL-10 from human PBMCs.
Lenalidomide (CC-5013) downregulates the production of IL-6 directly and also by inhibiting multiple myeloma (MM) cells and bone marrow stromal cells (BMSC) interaction.
Orally administered lenalidomide (250 mg/kg per day) reduces vascularization and total microvascular length in a rat mesenteric window assay.

物理化学性质&存储条件

分子量 259.27
分子式 C13H13N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

参考文献

1. Krönke J, et al. Oncoimmunology. 2014 Jul 3;3(7):e941742.

2. Kotla V, et al. J Hematol Oncol. 2009 Aug 12;2:36.

3. Lopez-Girona A, et al. Leukemia. 2012 Nov;26(11):2326-35.

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