Lasofoxifene | SERM | Probechem Biochemicals

Chemical Structure : Lasofoxifene

CAS No.: 180916-16-9

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Lasofoxifene (CP-336156, CP-336,156)

货号: PC-24543Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2380	In stock
250 mg		Get quote

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生物&药学活性

Lasofoxifene (CP-336156, CP-336,156) is a potent, orally active, nonsteroidal selective estrogen receptor modulator (SERM), binds selectively and with high affinity to the human ERα with IC50 of 1.5 nM.
Lasofoxifene (CP-336156, CP-336,156) is potent and efficacious as estrogen at preventing bone loss and lowering total serum cholesterol in rats, shows no estrogen-like proliferative effects on breast and uterine tissue.
Lasofoxifene (CP-336156, CP-336,156) induced apoptosis and p53 expression with a concomitant decrease in the number of tartrate-resistant acid phosphatase-positive multinuclear cells in rat bone marrow cell cultures in vitro.
Lasofoxifene (CP-336156, CP-336,156) decreased total serum cholesterol and fat body mass and had no effect on lean body mass in female rats.

物理化学性质&存储条件

分子量	413.56
分子式	C28H31NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R,6S)-6-Phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

参考文献

1. Ke HZ, et al. Endocrinology. 2000 Apr;141(4):1338-44.

2. Rosati RL, et al. J Med Chem. 1998 Jul 30;41(16):2928-31.

Lasofoxifene (CP-336156, CP-336,156)

生物&药学活性

物理化学性质&存储条件

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Lasofoxifene (CP-336156, CP-336,156)

生物&药学活性

物理化学性质&存储条件

参考文献

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