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首页-小分子抑制剂&激动剂-Others-Other Targets-Lalistat-2
Lalistat-2

Chemical Structure : Lalistat-2

CAS No.: 1234569-09-5

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Lalistat-2 (L-stat)

货号: PC-20889Not For Human Use, Lab Use Only.

Lalistat-2 (L-stat) is a specific inhibitor of lysosomal acid lipase (LAL) with IC50 of 152 nM, shows no significant activity against pancreatic lipase or lipoprotein lipase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lalistat-2 (L-stat) is a specific inhibitor of lysosomal acid lipase (LAL) with IC50 of 152 nM, shows no significant activity against pancreatic lipase or lipoprotein lipase.
Lalistat 2 interferes with neutral lipolysis.
Lalistat 2 binds to active center of neutral lipid hydrolases.

物理化学性质&存储条件

分子量 296.39
分子式 C13H20N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1-Piperidinyl)-1,2,5-thiadiazol-3-yl 1-piperidinecarboxylate

参考文献

1. Anton I Rosenbaum, et al. J Med Chem. 2010 Jul 22;53(14):5281-9.

2. Bradić I, et al. Mol Metab. 2022 Jul;61:101510.

3. Hamilton J, et al. Clin Chim Acta. 2012 Aug 16;413(15-16):1207-10.

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