Laforin inhibitor 9c

Chemical Structure : Laforin inhibitor 9c

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货号: PC-24364Not For Human Use, Lab Use Only.

Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs.

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生物&药学活性

Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs.
Laforin inhibitor 9c efficiently blocks laforin-mediated glucan dephosphorylation inside the cell and possess favorable pharmacokinetic properties in mice.

物理化学性质&存储条件

分子量	586.06
分子式	C28H28ClN3O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((2-(2-((3-Chloro-4-phenoxyphenyl)amino)-2-oxoacetamido)cyclohexyl)amino)-2-oxo-1-phenylethanesulfonic Acid

参考文献

1. Lin J, et al. J Med Chem. 2025 Apr 16. doi: 10.1021/acs.jmedchem.4c02580.