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首页-抗体药物偶连体和PROTACs-PROTAC-LZK PROTAC 17
LZK PROTAC 17

Chemical Structure : LZK PROTAC 17

CAS No.: 2763268-85-3

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LZK PROTAC 17

货号: PC-24506Not For Human Use, Lab Use Only.

LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM.
LZK PROTAC 17 (250 nM) reduces colony formation of CAL33 and DETROIT562.
LZK PROTAC 17 induces dose- and time-dependent degradation of LZK in HNSCC cells harboring MAP3K13 amplification.

物理化学性质&存储条件

分子量 909.11
分子式 C48H58F2N10O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4R)-1-((S)-2-((1r,3S)-3-(4-(2-((4-cyanopyridin-2-yl)amino)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)piperidin-1-yl)cyclobutane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Katerji M, et al. J Biol Chem. 2025 Mar 27:108452.

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