LY3295668 | Aurora A inhibitor | Probechem Biochemicals

Chemical Structure : LY3295668

CAS No.: 1919888-06-4

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LY3295668 (LY-329566, AK-01)

货号: PC-35756Not For Human Use, Lab Use Only.

LY3295668 (LY-3295668, AK-01) is a novel potent, highly selective, orally active Aurora-A kinase inhibitor with Ki of 0.8 nM, H446 AurA auto-P IC50 of 0.6 nM.

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5 mg	￥2980	In stock
10 mg	￥4880	In stock
25 mg	￥7980	In stock
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生物&药学活性

LY3295668 (LY-3295668, AK-01) is a novel potent, highly selective, orally active Aurora-A kinase inhibitor with Ki of 0.8 nM, H446 AurA auto-P IC50 of 0.6 nM.
LY3295668 displays >1000-fold selectivity over Aur-B, 5/386 kinases were potently inhibited by LY3295668 (<10 nM) and none of these kinases overlapped with targets of the other AurAi (MK5108, alisertib), and no inhibition of SYK.
LY3295668 is cytotoxic to RB1 mutant cancer cancaer cells (NCI-H446 cell IC50=0.752 uM), causes durable regression of RB1mut tumor xenografts.

物理化学性质&存储条件

分子量	489.952
分子式	C24H26ClF2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4R)-1-(3-chloro-2-fluorobenzyl)-4-((3-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid

参考文献

1. Gong X, et al. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.

LY3295668 (LY-329566, AK-01)

生物&药学活性

物理化学性质&存储条件

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LY3295668 (LY-329566, AK-01)

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物理化学性质&存储条件

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