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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-LY-364947
LY-364947

Chemical Structure : LY-364947

CAS No.: 396129-53-6

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LY-364947 (HTS466284)

货号: PC-24919Not For Human Use, Lab Use Only.

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II.

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5 mg ￥480 In stock
10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II.

物理化学性质&存储条件

分子量 272.31
分子式 C17H12N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

参考文献

1. Peng SB, et al. Biochemistry, 2005, 44(7), 2293-2304.

2. Oka M, et al. Blood, 2008, 111(9), 4571-4579.

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