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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-LXE408
LXE408

Chemical Structure : LXE408

CAS No.: 1799330-15-6

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LXE408 (LXE-408)

货号: PC-25293Not For Human Use, Lab Use Only.

LXE408 is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM).

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LXE408 is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM).

物理化学性质&存储条件

分子量 443.44
分子式 C23H18FN7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide

参考文献

1. Nagle A, et al. J Med Chem. 2020 Oct 8;63(19):10773-10781.

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