Telotristat ethyl (LX1606) | TPH inhibitor | Probechem Biochemicals

Chemical Structure : LX1606

CAS No.: 1033805-22-9

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LX1606 (Telotristat ethyl, LX 1606, LX-1606)

货号: PC-43356Not For Human Use, Lab Use Only.

Telotristat ethyl (LX1606) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

Telotristat ethyl (LX1606) is a potent, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM.
Telotristat ethyl (LX1606) demonstrates potential for the treatment of carcinoid syndrome.

物理化学性质&存储条件

分子量	574.9819
分子式	C27H26ClF3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

参考文献

1. Margolis KG, et al. Gut. 2014 Jun;63(6):928-37.

2. Kulke MH, et al. Endocr Relat Cancer. 2014 Oct;21(5):705-14.

3. Kulke MH, et al. J Clin Oncol. 2017 Jan;35(1):14-23.

4. Kim JJ, et al. Am J Physiol Gastrointest Liver Physiol.

LX1606 (Telotristat ethyl, LX 1606, LX-1606)

生物&药学活性

物理化学性质&存储条件

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LX1606 (Telotristat ethyl, LX 1606, LX-1606)

生物&药学活性

物理化学性质&存储条件

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