LV-320 |CAS 2449093-46-1 Probechem Biochemicals

Chemical Structure : LV-320

CAS No.: 2449093-46-1

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LV-320 (LV320;LV 320)

货号: PC-35540Not For Human Use, Lab Use Only.

LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays.

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10 mg	￥5980	In stock
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生物&药学活性

LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assay.
LV-320 binds to ATG4B and is an uncompetitive inhibitor of ATG4B with Kd of 16 uM.
LV-320 blocks starvation-induced autophagic fux in vitro; also inhibit ATG4A with an IC50 of 35.5 uM, but does not shows meaningful inhibition for caspase-3 or cathepsin B.
LV-320 reduces autophagic fux in vitro and is bioavailable and active in vivo.
LV-320 is a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.

物理化学性质&存储条件

分子量	520.102
分子式	C29H26ClNO2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(((4-(2-(7-chloroquinolin-4-yl)vinyl)phenyl)(phenethylthio)methyl)thio)propanoic acid

参考文献

1. Bosc D, et al. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.

LV-320 (LV320;LV 320)

生物&药学活性

物理化学性质&存储条件

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LV-320 (LV320;LV 320)

生物&药学活性

物理化学性质&存储条件

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