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首页-小分子抑制剂&激动剂-Others-Other Targets-LRI-305
LRI-305

Chemical Structure : LRI-305

CAS No.: 3125100-00-4

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LRI-305 (LRI305)

货号: PC-27187Not For Human Use, Lab Use Only.

LRI-305 (LRI305) is a selective antagonist of Leukemia Inhibitory Factor (LIF) receptor (LIFR), effectively inhibits LIF/LIFR interaction with with IC50 of 0.86 uM in Alpha Screen assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LRI-305 (LRI305) is a selective antagonist of Leukemia Inhibitory Factor (LIF) receptor (LIFR), effectively inhibits LIF/LIFR interaction with with IC50 of 0.86 uM in Alpha Screen assays.
LRI-305 reverses the LIF-induced proliferative effects in MKN45 cells with IC50 of 0.7 uM.
LRI-305 exhibits dose-dependent inhibition of STAT3-mediated transcriptional activity with IC50 of 2.9 uM in HepG2 cells transiently transfected with a l STAT3-inducible elements (SIE) luciferase reporter plasmid.
LRI-305 effectively impairs LIF-induced STAT3 signaling and its downstream oncogenic and immunosuppressive effects, including enhanced cell proliferation, EMT, migration, and PD-L1 upregulation in gastric cancer cells.
Combined anti–PD-L1/LRI-305 treatment significantly increased the frequency of double-positive HLA-DR/CD38 activated T cells compared with exposure to conditioned media derived from LIF-treated MKN45 cells alone.

物理化学性质&存储条件

分子量 464.65
分子式 C33H36O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8S,11R,13S,14S)-13-methyl-11-(2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)-1,6,7,8,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione

参考文献

1. Cristina Di Giorgio, et al. Transl Oncol. 2026 Aug:70:102848.

2. Rosa De Gregorio, et al. J Med Chem. 2025 Oct 9;68(19):20037-20059.

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