LPM4870108 | Trk inhibitor | Probechem Biochemicals

Chemical Structure : LPM4870108

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LPM4870108 (LPM-4870108)

货号: PC-25354Not For Human Use, Lab Use Only.

LPM4870108 is a next-generation, potent pan-Trk inhibitor with IC50 of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkAG595R and TrkAG667C, respectively, shows high selectivity over ALK (IC50=182 nM).

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生物&药学活性

LPM4870108 is a next-generation, potent pan-Trk inhibitor with IC50 of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkAG595R and TrkAG667C, respectively, shows high selectivity over ALK (IC50=182 nM).
LPM4870108 (5, 10, or 20 mg/kg) produced significant inhibition of tumor growth both in wild-type NTRK fusion mutation cells (Ba/F3 LMNA-NTRK1cells and Ba/F3 ETV6-NTRK3 cells) and drug-resistant mutation cells (Ba/F3 ETV6-NTRK3-G623R cells and Ba/F3 LMNA-NTRK1-G595R).
LPM4870108 is more efficacious and safer against tumor growth than LOXO-195.

物理化学性质&存储条件

分子量	410.41
分子式	C20H19FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,3'E,4'E)-5'-fluorospiro[cyclopropane-1,6'-4-oxa-7-aza-2(4,3)-morpholina-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridinacyclooctaphan]-8'-one

参考文献

1. Liu B, et al. J Clin Invest. 2025 Aug 12:e194879.

LPM4870108 (LPM-4870108)

生物&药学活性

物理化学性质&存储条件

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LPM4870108 (LPM-4870108)

生物&药学活性

物理化学性质&存储条件

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