LPA1 antagonist Compound A

Chemical Structure : LPA1 antagonist Compound A

加入收藏

货号: PC-24539Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LPA1 antagonist Compound A is a potent, selective, and brain penetrant lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 18.8 nM in 35S-GTPγS binding assays, and IC50 of 12.03 nM in Ca2+ influx assays.
Compound A shows IC50 of 27 nM in β-arrestin assay, >25-fold selective over other LPA receptors.
Compound A demonstratesa nti-hyperalgesic effects in the IPGP model mice.

物理化学性质&存储条件

分子量	548.05
分子式	C30H26ClNO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-[4'-(5-chloro-3-{[(1-phenylethoxy)carbonyl] amino}thiophen-2-yl)-2′-methoxy-[1,1′-biphenyl]-4-yl] cyclopropanecarboxylic acid

参考文献

1. Neyama H, et al. J Pharmacol Sci. 2025 Jun;158(2):139-142.