LP-182 | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : LP-182

加入收藏

LP-182 (LP182)

货号: PC-49266Not For Human Use, Lab Use Only.

LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways.
LP-182 displays >100-fold selectivity against a broad panel of 321 human protein kinases.
LP-182 ameliorated of splenomegaly and fibrotic disease phenotypes, and extended overall survival in the myeloproliferative leukemia oncogene (MPL W515L) mouse model of myelofibrosis (MF).
Oral treatment of MPLW515L mice with LP-182 also resulted in renormalization of blood cell populations and attenuation of downstream protein kinase B (PKB/AKT) and extracellular signalregulated protein kinase 1/2 (ERK1/2) signaling activity in bone marrow and isolated splenocytes.

物理化学性质&存储条件

分子量	1093.287
分子式	C45H42ClF4IN8O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-(3-(4-(7-(6-chloro-5-((4-fluorophenyl)sulfonamido)pyridin-3-yl)quinoxalin-2-yl)piperazin-1-yl)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

参考文献

1. Brian D Ross, et al. Nat Commun. 2022 Aug 17;13(1):4730.

LP-182 (LP182)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LP-182 (LP182)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.