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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-LMT2368
LMT2368

Chemical Structure : LMT2368

CAS No.: 2961608-06-8

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LMT2368 (LMT-2368)

货号: PC-25673Not For Human Use, Lab Use Only.

LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling.
LMT2368 inhibited ASC oligomerization and pyroptosis while maintaining excellent safety margins (CC50 > 50 μM).
LMT2368 (10 mg/kg) reduced bronchoalveolar lavage fluid immune cell infiltration by 68% in murine model of LPS-induced acute lung injury, suppressed pro-inflammatory cytokine release (IL-1β/IL-6/TNF-α), and preserved lung histoarchitecture.
LMT2368 showed selectivity for NLRP3 inhibition without affecting TNF-α/IL-6 production during TLR4 priming in monocytic cell lines.

物理化学性质&存储条件

分子量 332.68
分子式 C14H9ClF4N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea

参考文献

1. Nguyen TU, et al. Pharmaceutics. 2025 Sep 23;17(10):1241.

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