LL-00071210 | PI3Kδ inhibitor | Probechem Biochemicals

Chemical Structure : LL-00071210

加入收藏

LL-00071210 (LL00071210)

货号: PC-38789Not For Human Use, Lab Use Only.

LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively.
LL-00071210 demonstrated specific inhibitory action against PI3Kδ isoform with >100-fold selectivity over closely related PI3Kγ isoform.
LL-00071210 potently inhibited IL2 (A), TNF-α (B) and IFN-γ (C) secretion from human PBMC's on stimulation with anti-CD3/CD28.
LL-00071210 showed acceptable pharmacokinetic profile with good oral bioavailability in rodents.
In rodent arthritis model, treatment with LL-00071210 led to dosedependent inhibition of disease severity, along with histopathological
improvements in joint structure.
LL-00071210 also demonstrated good combination potential with methotrexate at sub-therapeutic doses.

物理化学性质&存储条件

分子量	400.417
分子式	C22H17FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-amino-6-((1-(7-fluoro-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile

参考文献

1. Vijay Kanoje, et al. Eur J Pharmacol. 2022 May 27;175054.

LL-00071210 (LL00071210)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LL-00071210 (LL00071210)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.