LJ-4378 | A2AAR agonist, A3AR antagonist | Probechem Biochemicals

Chemical Structure : LJ-4378

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LJ-4378 (LJ4378)

货号: PC-25685Not For Human Use, Lab Use Only.

LJ-4378 is a dual-acting ligand with A2AAR agonist (EC50=80.3 nM for cAMP formation, binding Ki=7.19 nM) and A3 adenosine receptor (A3AR, binding Ki=11.8 nM) antagonist activity.

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生物&药学活性

LJ-4378 is a dual-acting ligand with A2AAR agonist (EC50=80.3 nM for cAMP formation, binding Ki=7.19 nM) and A3 adenosine receptor (A3AR, binding Ki=11.8 nM) antagonist activity.

物理化学性质&存储条件

分子量	333.41
分子式	C15H19N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4R)-2-(6-Amino-2-(hex-1-ynyl)-9H-purin-9-yl)- tetrahydrothiophene-3,4-diol

参考文献

1. Kim K, et al. Int J Obes (Lond). 2022 Dec;46(12):2128-2136.

2. Xiyan Hou, et al. J Med Chem. 2012 Jan 12;55(1):342-56.

LJ-4378 (LJ4378)

生物&药学活性

物理化学性质&存储条件

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LJ-4378 (LJ4378)

生物&药学活性

物理化学性质&存储条件

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