Chemical Structure : LILRB4 inhibitor compound 4
CAS No.:
1101176-31-1
LILRB4 inhibitor compound 4
货号: PC-28144Not For Human Use, Lab Use Only.
LILRB4 inhibitor compound 4 is a high affinity, brain-penetrant leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3/CD85k) inhibitor, inhibits LILRB4-ApoE interaction with IC50 of 40.6 nM in ELISA assays.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
LILRB4 inhibitor compound 4 is a high affinity, brain-penetrant leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3/CD85k) inhibitor, inhibits LILRB4-ApoE interaction with IC50 of 40.6 nM in ELISA assays.
LILRB4 inhibitor compound 4 suppresses LILRB4-dependent signaling, attenuates neuroinflammation, restores amyloid-β uptake, and shows no cytotoxicity in iPSC-derived human microglia.
LILRB4 inhibitor compound 4 exhibits high-affinity binding with MST Kd of 17.5 nM for ecombinant extracellular domain of mouse LILRB4.
LILRB4 inhibitor compound 4 (10 mg/kg, PO, QD) improved Y-maze performance and reduced regional Aβ42 levels, inflammatory cytokines, and CD86-positive microglia in male and female 5xFAD mice.
物理化学性质&存储条件
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分子量
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543.59
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分子式
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C28H32F3N5O3
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-methyl-1-oxo-1-(4-(4-(5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzyl)piperazin-1-yl)pentan-2-yl)acetamide
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参考文献
1. Abdel-Rahman SA, et al. Bioorg Chem. 2026 Sep 10;182:110508.
