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LIBX-A403

Chemical Structure : LIBX-A403

CAS No.:

LIBX-A403

货号: PC-25149Not For Human Use, Lab Use Only.

LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.

规格 价格 库存 数量
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.
LIBX-A403 protect cells from ferroptosis, prevents ferroptotic cell death in different cell models.
LIBX-A403 inhibits ferroptosis through an ACSL4-dependent mechanism.

物理化学性质&存储条件

分子量 363.37
分子式 C21H17NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl (2E)-3-(2-benzoyl-3-acetamido-1-benzofuran-5-yl)prop-2-enoate

参考文献

1. Charnelle E, et al. J Med Chem. 2025 Jul 19. doi: 10.1021/acs.jmedchem.5c00739.

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