Chemical Structure : LIBX-A403
货号: PC-25149Not For Human Use, Lab Use Only.
LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.
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LIBX-A403 is a potent, selective Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) inhibitor with IC50 of 49 nM and MST KD of 0.29 uM, with no activity against ACSL3.
LIBX-A403 protect cells from ferroptosis, prevents ferroptotic cell death in different cell models.
LIBX-A403 inhibits ferroptosis through an ACSL4-dependent mechanism.
分子量 | 363.37 | |
分子式 | C21H17NO5 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Charnelle E, et al. J Med Chem. 2025 Jul 19. doi: 10.1021/acs.jmedchem.5c00739.
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