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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-LFW273
LFW273

Chemical Structure : LFW273

CAS No.: 2801580-58-3

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LFW273 (LFW-273)

货号: PC-24309Not For Human Use, Lab Use Only.

LFW273 is a specific, orally bioavailable small molecule inhibitor of zinc-finger transcription factor Snail with binding Kd of 1.7 uM, inhibits CREB-binding protein (CBP)-Snail interaction with Kd of 7.3 uM in MST assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LFW273 is a specific, orally bioavailable small molecule inhibitor of zinc-finger transcription factor Snail with binding Kd of 1.7 uM, inhibits CREB-binding protein (CBP)-Snail interaction with Kd of 7.3 uM in MST assays.
LFW273 reduces the binding of Snail with CBP in a dose-dependent manner in streptavidin pull-down assay.
LFW273 inhibits Snail expression at the protein but not the mRNA level in a dose-dependent manner in cultured murine embryonic vascular endothelial cells (ECs), substantially reduces secreted CCL5 and CXCL10.
LFW273 markedly suppresses the migration capacity of THP-1 monocytes in the presence of conditioned medium derived from LFW273-treated Snailfl/fl ECs.
LFW273 (25-50 mg/kg, orally, sterile normal saline (0.9% NaCl solution)) attenuates atherosclerosis progression in a canonical mouse model, decreases necrotic core area in atherosclerotic plaques, dislays potent anti-atherosclerotic effects in mice.

物理化学性质&存储条件

分子量 408.52
分子式 C22H24N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole

参考文献

1. Ren BX, et al. Acta Pharmacol Sin. 2025 Mar 25. doi: 10.1038/s41401-025-01519-5.

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