LDR102 | ROR1 inhibitor | Probechem Biochemicals

Chemical Structure : LDR102

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LDR102 (ROR1 inhibitor 19h)

货号: PC-23530Not For Human Use, Lab Use Only.

LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity.

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生物&药学活性

LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity.
LDR102 exhibits antitumor activity in lung cancer and breast cancer cell lines (IC50: 0.36-1.37 μM).
LDR102 induces the apoptosis of tumor cells.
LDR102 significantly suppressed tumor growth in a mouse model without obvious toxicity.

物理化学性质&存储条件

分子量	541.61
分子式	C33H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1H-Pyrazolo[3,4-b]pyridin-4-yl)ethynyl)-N-(3-(4-(methoxymethoxy)phenyl)-1-methyl-1H-indol-6-yl)-4-methylbenzamide

参考文献

1. Dongdong Luo, et al. J Med Chem. 2024 Jul 11;67(13):10655-10686.

LDR102 (ROR1 inhibitor 19h)

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物理化学性质&存储条件

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LDR102 (ROR1 inhibitor 19h)

生物&药学活性

物理化学性质&存储条件

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