L687

Chemical Structure : L687

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货号: PC-25780Not For Human Use, Lab Use Only.

L687 is a potent, specific TRPC3/C6/C7 activator, induces cellular antisense oligonucleotide (ASO) uptake, also induces dextran uptake and increases endocytosis.

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生物&药学活性

L687 is a potent, specific TRPC3/C6/C7 activator, induces cellular antisense oligonucleotide (ASO) uptake, also induces dextran uptake and increases endocytosis.
L687 dose-dependently increased Ca2+ influx via TRPC3/C6/C7.
L687 does not activate TRP channel (TRPC1, C2, C4, C5, A1, V1 and M2) via overexpression in HEK297 cells.
L687 (0.03-30 uM) induces intracellular uptake of oligonucleotides in A549 cells
L687 inreases ASO uptake and activity in tumours of xenograft mice.

物理化学性质&存储条件

分子量	485.03
分子式	C26H33ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazineacetamide, 4-[2-chloro-4-(1-piperidinylcarbonyl)phenyl]-N-(2-ethoxyphenyl)-

参考文献

1. Hiroto Kohashi, et al. Nucleic Acids Res. 2024 May 22;52(9):4784-4798.

L687

生物&药学活性

物理化学性质&存储条件

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L687

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物理化学性质&存储条件

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