L-165041 | PPARδ agonist | Probechem Biochemicals

Chemical Structure : L-165041

CAS No.: 79558-09-1

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L-165041 (L 165041;L165041)

货号: PC-45781Not For Human Use, Lab Use Only.

L-165041 (L165041) is a selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ.

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25 mg	￥1380	In stock
50 mg	￥2280	In stock
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生物&药学活性

L-165041 (L165041) is a selective PPARδ agonist with Ki of 6 nM, >120 fold selectivity over PPARγ.
L-165041 inhibits cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.
L-165041 inhibits rat VSMC proliferation in a dose dependent manner by blocking G(1) to S phase progression and repressing the phosphorylation of Rb, also inhibits PDGF-induced expression of cyclin D1 and CDK4.
L-165041 significantly lowers plasma cholesterol without major changes in very low or low density lipoproteins in db/db mice.

物理化学性质&存储条件

分子量	402.4377
分子式	C22H26O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-

参考文献

1. Leibowitz MD, et al. FEBS Lett. 2000 May 19;473(3):333-6.

2. Rival Y, et al. Eur J Pharmacol. 2002 Jan 25;435(2-3):143-51.

3. Lim HJ, et al. Atherosclerosis. 2009 Feb;202(2):446-54.

L-165041 (L 165041;L165041)

生物&药学活性

物理化学性质&存储条件

参考文献

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L-165041 (L 165041;L165041)

生物&药学活性

物理化学性质&存储条件

参考文献

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