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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-L-161240
L-161240

Chemical Structure : L-161240

CAS No.: 183298-68-2

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L-161240 (L-161,240)

货号: PC-26545Not For Human Use, Lab Use Only.

L-161240 (L-161,240) is an antibacterial agent that inhibit lipid A biosynthesis, inhibits LpxC with IC50 of 26 nM and inhibition constant (Ki) of 50 nM, displays MIC of about 1 ug /mL against Escherichia coli.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

L-161240 (L-161,240) is an antibacterial agent that inhibit lipid A biosynthesis, inhibits LpxC with IC50 of 26 nM and inhibition constant (Ki) of 50 nM, displays MIC of about 1 ug /mL against Escherichia coli.

物理化学性质&存储条件

分子量 308.33
分子式 C15H20N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide

参考文献

1. Onishi HR, et al. Science. 1996 Nov 8;274(5289):980-2.

2. Clements JM,et al. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9.

3. Chen MH, et al. Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8.

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