Kv7 blocker compound 106

Chemical Structure : Kv7 blocker compound 106

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货号: PC-27787Not For Human Use, Lab Use Only.

Kv7 blocker compound 106 (C106) is a potent, subtype-selective Kv7 blocker with IC50 of 33.1 nM for Kv7.2/3 channels, without affecting cardiac Kv7.1 channels.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Kv7 blocker compound 106 (C106) is a potent, subtype-selective Kv7 blocker with IC50 of 33.1 nM for Kv7.2/3 channels, without affecting cardiac Kv7.1 channels.
C106 (30 nM) inhibits roughly 50% of the current (IDRUG/ICTL at 0 mV was 43.9% ± 6.0%), with no significant change in V1/2.
C106 has IC50 of 40 ± 1 nM for Kv7.2, 40 ± 3 nM for Kv7.3 A315T mutant channels (Kv7.3*), and 15 ± 3 nM for Kv7.4 channels in CHO cells expressing homomeric Kv7.2, Kv7.3, and Kv7.4 channels, does not affect Kv7.1 currents.

物理化学性质&存储条件

分子量	493.51
分子式	C28H23F4N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)-2,2-diphenylacetamide

参考文献

1. Ciaglia T, et al. Angew Chem Int Ed Engl. 2026 Aug 22:e7948330.