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首页-小分子抑制剂&激动剂-Immunology/Inflammation-PD-1/PD-L1-Kukoamine B
Kukoamine B

Chemical Structure : Kukoamine B

CAS No.: 164991-67-7

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Kukoamine B

货号: PC-27897Not For Human Use, Lab Use Only.

Kukoamine B is a natural alkaloid compound and potent dual inhibitor for both lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), also is an inhibitor of membrane PD-1/PD-L1 interaction, thereby restoring T-cell function.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Kukoamine B is a natural alkaloid compound and potent dual inhibitor for both lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), also is an inhibitor of membrane PD-1/PD-L1 interaction, thereby restoring T-cell function.
Kukoamine B neutralizes LPS and CpG DNA and prevents them from interacting with mouse macrophages.
Kukoamine B selectively inhibits LPS- and CpG DNA-induced signal transduction and expression of pro-inflammatory mediators without interfering with signal pathways or cell viability in macrophages.
Kukoamine B protects mice challenged with heat-killed Escherichia coli, and reduces the circulatory levels of LPS and TNF-α.
Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes.

物理化学性质&存储条件

分子量 530.67
分子式 C28H42N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-Aminopropyl)-3-(3,4-dihydroxyphenyl)-N-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide

参考文献

1. Qin WT, et al. Exp Ther Med. 2015 Mar;9(3):725-732.

2. Yang D, et al. Oncotarget. 2016 Sep 6;7(36):57498-57513.

3. Liu X, et al. Br J Pharmacol. 2011 Mar;162(6):1274-90.

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