Keap1-p-p62 inhibitor 13 | Nrf2 inhibitor, Keap1-p-p62 inhibitor

Chemical Structure : Keap1-p-p62 inhibitor 13

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Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1)

货号: PC-27016Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1) is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.11 uM, high selectivity over inhibition of Keap1-Nrf2 interaction.
Keap1-p-p62 inhibitor 13 specifically inhibitsNrf2 activity in p62 aberrant hepatocellular carcinoma (HCC) cells by selectively disrupting Keap1-p-p62 interaction and normalizing Nrf2 ubiquitination.
Keap1-p-p62 inhibitor 13 sensitizes p62 aberrant HCC to ferroptosis induced by sorafenib (TGI = 95.3%).

物理化学性质&存储条件

分子量	613.73
分子式	C33H35N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-((N-((1H-tetrazol-5-yl)methyl)-2,4,6-trimethylphenyl)sulfonamido)naphthalen-1-yl)oxy)-2-(4-(tert-butyl)phenyl)acetic acid

参考文献

1. Ziquan Zhao, et al. J Med Chem. 2026 Jun 11;69(11):13141-13164.

Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1)

生物&药学活性

物理化学性质&存储条件

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Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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