Keap1-Nrf2 inhibitor 28

Chemical Structure : Keap1-Nrf2 inhibitor 28

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货号: PC-25376Not For Human Use, Lab Use Only.

Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays.
Keap1-Nrf2 inhibitor 28 markedly reduces the expression of NLRP3, a key pattern-recognition receptor (PRR) domain of the inflammasome in macrophage-derived THP-1 cells, prevents the cleavage of gasdermin D (GSDMD), a process otherwise mediated by active caspase-1.
Keap1-Nrf2 inhibitor 28 shows anti-inflammatory effects by downregulating NLRP3 inflammasome and STING signalling.
Keap1-Nrf2 inhibitor 28 activates specific Nrf2-controlled genes and key immune signalling pathways.

物理化学性质&存储条件

分子量	517.62
分子式	C31H35NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(7-(2-(cycloheptylamino)-2-oxoethoxy)naphthalen-2-yl)-3-(7-methyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propanoic acid

参考文献

1. Lin C, et al. Angew Chem Int Ed Engl. 2025 Aug 21:e202508121.