欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-KYP-2047
KYP-2047

Chemical Structure : KYP-2047

CAS No.: 796874-99-2

加入收藏

KYP-2047 (KYP2047)

货号: PC-38478Not For Human Use, Lab Use Only.

KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4980 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.
KYP-2047 reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain in animal models of Parkinson's disease.
KYP-2047 also reduced tongue squamous cell-carcinoma (TSCC) cell viability at 50 and 100 uM, significantly reduced tumor burden and tumor weight, decreasing also angiogenesis markers VEGF and eNOS.

物理化学性质&存储条件

分子量 339.44
分子式 C20H25N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

参考文献

1. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51.

2. Jalkanen AJ, et al. Neurosci Lett. 2011 Sep 15;502(2):107-11.

3. Myöhänen TT, et al. Br J Pharmacol. 2012 Jun;166(3):1097-113.

4. Scuderi SA, et al. Oncotarget. 2021 Dec 7;12(25):2459-2473.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: