KYN-101 (KYN101)

Chemical Structure : KYN-101

CAS No.: 2247950-73-6

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货号: PC-38597Not For Human Use, Lab Use Only.

KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
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生物&药学活性

KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.
KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO.

物理化学性质&存储条件

分子量	386.434
分子式	C22H19FN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-Indol-3-yl)ethyl)-5-(5-fluoropyridin-3-yl)-3-methylpyrazolo[1,5-a]pyrimidin-7-amine

参考文献

1. Luis Felipe Campesato, et al. Nat Commun. 2020 Aug 11;11(1):4011.

KYN-101 (KYN101)

生物&药学活性

物理化学性质&存储条件

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KYN-101 (KYN101)

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物理化学性质&存储条件

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