KYH1942 | IL-33 antagonist | Probechem Biochemicals

Chemical Structure : KYH1942

加入收藏

KYH1942 (KYH-1942)

货号: PC-26287Not For Human Use, Lab Use Only.

KYH1942 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KYH1942 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation.
KYH1942 reduces IL-33-induced Foxp3 and Ki-67 expression in a dose-dependent manner, downregulates key immune checkpoint molecules including PD-1, CTLA-4, TIM3, and TIGIT in Treg cells.
KYH1942 shows directly bind to IL-33(C259A) with MST Kd of 48.37 uM.
KYH1942 is capable of inhibiting the IL-33/ST2 interaction, achieving 43–53% inhibition at 0.3 µM and 55–68% inhibition at 3 µM. reduces stability and proliferation of tumor-infiltrating Treg cells ex vivo.

物理化学性质&存储条件

分子量	350.30
分子式	C16H13F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-morpholino-2-(4-(trifluoromethyl)phenyl)oxazolo[5,4-d]pyrimidine

参考文献

1. Kim Y, et al. Chembiochem. 2026 Mar 13;27(5):e202500417.

KYH1942 (KYH-1942)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

KYH1942 (KYH-1942)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.