KY-455 | ACAT inhibitor | Probechem Biochemicals

Chemical Structure : KY-455

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KY-455 (KY455)

货号: PC-27355Not For Human Use, Lab Use Only.

KY-455 is an anti-oxidative ACAT inhibitor, inhibits rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 of 0.4, 0.9, 2.9 and 4.1 uM, respectively.

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生物&药学活性

KY-455 is an anti-oxidative ACAT inhibitor, inhibits rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 of 0.4, 0.9, 2.9 and 4.1 uM, respectively.
KY-455 also inhibits rabbit plasma and LDL-peroxidation (IC50: 0.4 and 1.7 micromol/l, respectively).
KY-455 (30 mg/kg/day) for 8 days markedly lowered serum esterified, free, low-density lipoprotein (LDL)-cholesterol, and hepatic esterified cholesterol levels in rabbits fed a high-cholesterol diet.
KY-455 (30 mg/kg) significantly inhibited ex vivo hepatic ACAT activity in hamsters.
KY-455 protects foam cells from oxidative stress and effectively reduces cholesterol levels.

物理化学性质&存储条件

分子量	316.49
分子式	C20H32N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,3-Dihydro-4,6-dimethyl-1-pentyl-1H-indol-7-yl)-2,2-dimethylpropanamide

参考文献

1. Nakamura S, et al. Arzneimittelforschung. 2004;54(2):102-8.

KY-455 (KY455)

生物&药学活性

物理化学性质&存储条件

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KY-455 (KY455)

生物&药学活性

物理化学性质&存储条件

参考文献

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