KTX207 | PDE4 PROTAC | Probechem Biochemicals

Chemical Structure : KTX207

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KTX207 (KTX-207)

货号: PC-24472Not For Human Use, Lab Use Only.

KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively.

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生物&药学活性

KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively.
KTX207 is highly selective for PDE4 shortforms over longforms.
KTX207 degrades PDE4D shortform with high selectivity at sub-nanomolar concentration via the ubiquitin-proteasomal system
KTX207 is more effective at increasing cAMP levels than conventional inhibitor BI 1015550.
KTX207 can suppress cancer cell growth in 2D and 3D cultures of A549 cells.

物理化学性质&存储条件

分子量	882.14
分子式	C47H63N9O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(1-(9-((2-(1-((S)-4-((1-(hydroxymethyl)cyclobutyl)amino)-5-oxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)piperidin-4-yl)pyrimidin-5-yl)oxy)nonyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Sin YY. Et al. FEBS J. 2024 Dec 13. doi: 10.1111/febs.17359.

KTX207 (KTX-207)

生物&药学活性

物理化学性质&存储条件

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KTX207 (KTX-207)

生物&药学活性

物理化学性质&存储条件

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