KTI-240

Chemical Structure : KTI-240

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货号: PC-25396Not For Human Use, Lab Use Only.

KTI-240 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 2.3 uM in RPE-1 cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

KTI-240 is a small molecule inhibitor that covalently bind to cysteine-51 (Cys-51) in HPV16 E6, specifically inhibit HPV16 E6 mediate p53 degradation with EC50 of 2.3 uM in RPE-1 cells.
KTI-240 specifically reduce HPV+ cells viability with IC50 of 1-3 uM.
KTI-240 activates p53-dependent transcriptional programs associated with apoptosis and senescence, resulting in reduced tumor cell viability.
KTI-240 (50 mg/kg, s.c. injection) inhibits growth of HPV-16 expressing human cervical and oropharyngeal tumor cells in vivo.

物理化学性质&存储条件

分子量	491.57
分子式	C27H30FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-1-(4-(6-ethoxy-2-(2-(5-fluoro-4-methoxypyridin-2-yl)vinyl)quinazolin-4-yl)-2-ethylpiperazin-1-yl)prop-2-en-1-one

参考文献

1. Anne Rietz, et al. bioRxiv[Preprint]. 2025 Aug 28:2025.08.24.671874.

KTI-240

生物&药学活性

物理化学性质&存储条件

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KTI-240

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物理化学性质&存储条件

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