KT109 | DAGLβ inhibitor | Probechem Biochemicals

Chemical Structure : KT109

CAS No.: 1402612-55-8

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KT109 (KT-109)

货号: PC-61838Not For Human Use, Lab Use Only.

KT109 is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

KT109 is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα.
KT109 shows negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL and ABHD11.
KT109 disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages.
KT109 reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain; possesses one remaining off-target ABHD6 (IC50=16 nM).

物理化学性质&存储条件

分子量	422.5
分子式	C27H26N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-methanone

参考文献

1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.

2. Wilkerson JL, et al. Br J Pharmacol. 2016 May;173(10):1678-92.

3. Shin M, et al. Mol Pharm. 2017 Sep 13. doi: 10.1021/acs.molpharmaceut.7b00657.

KT109 (KT-109)

生物&药学活性

物理化学性质&存储条件

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KT109 (KT-109)

生物&药学活性

物理化学性质&存储条件

参考文献

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