KT-253 | MDM2 degrader | Probechem Biochemicals

Chemical Structure : KT-253

CAS No.: 2713618-08-5

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KT-253 (Seldegamadlin, KT253)

货号: PC-24182Not For Human Use, Lab Use Only.

Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer.

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2 mg	￥3980	In stock
5 mg	￥5980	In stock
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25 mg		Get quote

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生物&药学活性

Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer.
KT-253 inhibits the proliferation of cancer cell RS4;11 with IC50 of 0.3 nM.
KT-253 arrests the cell cycle at G2/M phase, and induces apoptosis.
KT 253 triggered rapid apoptosis and sustained tumor regression in p53 wild-type acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) xenograft models.

物理化学性质&存储条件

分子量	912.89
分子式	C48H52Cl2FN7O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide

参考文献

1. Yogesh K Chutake, et al. Mol Cancer Ther. 2024 Dec 9. doi: 10.1158/1535-7163.MCT-24-0306.

KT-253 (Seldegamadlin, KT253)

生物&药学活性

物理化学性质&存储条件

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KT-253 (Seldegamadlin, KT253)

生物&药学活性

物理化学性质&存储条件

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