KSC-34 | PDIA1 inhibitor | Probechem Biochemicals

Chemical Structure : KSC-34

CAS No.: 2226201-97-2

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KSC-34 (PDIA1 inhibitor KSC-34)

货号: PC-63459Not For Human Use, Lab Use Only.

KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site.
KSC-34 displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins.
KSC-34 significantly decreases the rate of secretion of a destabilized, amyloidogenic antibody light chain, thereby minimizing pathogenic amyloidogenic extracellular proteins in treated cells.

物理化学性质&存储条件

分子量	429.953
分子式	C21H28ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(2-((4-(methyl(4-phenylbutyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)acetamide

参考文献

1. Cole KS, et al. Biochemistry. 2018 Apr 3;57(13):2035-2043.

KSC-34 (PDIA1 inhibitor KSC-34)

生物&药学活性

物理化学性质&存储条件

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KSC-34 (PDIA1 inhibitor KSC-34)

生物&药学活性

物理化学性质&存储条件

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