KRAS G13D inhibitor 41

Chemical Structure : KRAS G13D inhibitor 41

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货号: PC-21544Not For Human Use, Lab Use Only.

KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS.

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KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS.

分子量	817.33
分子式	C43H45ClF4N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-((3S)-4-(7-(6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-2-methylenetetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)-3-((2S,5S)-1,3,4,5-tetrahydro-2,5-methanobenzo[c]azepin-9-yl)prop-2-en-1-one

1. Christian Nilewski, et al. ACS Medicinal Chemistry Letters, 2023.