KRAS4b inhibitor Compound 3

Chemical Structure : KRAS4b inhibitor Compound 3

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货号: PC-24580Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KRAS4b inhibitor Compound 3 is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), prevents its posttranslational processing and subsequent membrane attachment.
KRAS4b inhibitor Compound 3 (10 uM) decreased the level of membrane-bound GFP-KRAS4b G12D, with no or minimal effect on GFP-NRAS G12D in n HeLa cells and MEF cells expressing the G12V mutant of KRAS4b
KRAS4b inhibitor Compound 3 reduces KRAS4b G12V protein levels.
KRAS4b inhibitor Compound 3 blocks farnesylation and the subsequent posttranslational processing of KRAS4b in cells.

物理化学性质&存储条件

分子量	491.62
分子式	C23H29N3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-phenethyl-2-(4-((3-(vinylsulfonamidomethyl)pyrrolidin-1-yl)sulfonyl)phenyl)acetamide

参考文献

1. Maciag AE, et al. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2410766122.